Mechanical stress induces elastic fibre disruption and cartilage matrix increase in ligamentum flavum.

ABSTRACT: Lumbar spinal stenosis (LSS) is one of the most frequent causes of low back pain and gait disturbance in the elderly. Ligamentum flavum (LF) hypertrophy is the main pathomechanism of LSS, but the reason for its occurrence is not clearly elucidated. In this study, we established a novel animal model of intervertebral mechanical stress concentration and investigated the biological property of the LF. The LF with mechanical stress concentration showed degeneration with elastic fibres disruption and cartilage matrix increase, which are similar to the findings in hypertrophied LF from patients with LSS. By contrast, decreased Col2a1 expression was found in the LF at fixed levels, in which mechanical stress was strongly reduced. These findings indicate that mechanical stress plays a crucial role

SUBMITTER: Hayashi K 

PROVIDER: S-EPMC5638934 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature