HLA and Histo-Blood Group Antigen Expression in Human Pluripotent Stem Cells and their Derivatives.

ABSTRACT: One prerequisite for a successful clinical outcome of human pluripotent stem cell (hPSC) based therapies is immune compatibility between grafted cells/tissue and recipient. This study explores immune determinants of human embryonic stem cell lines (hESC) and induced human pluripotent stem cell (hiPSC) lines and hepatocyte- and cardiomyocyte-like cells derived from these cells. HLA class I was expressed on all pluripotent hPSC lines which upon differentiation into hepatocyte-like cells was considerably reduced in contrast to cardiomyocyte-like cells which retained class I antigens. No HLA class II antigens were found in the pluripotent or differentiated cells. Histo-blood group carbohydrate antigens SSEA-3/SSEA-4/SSEA-5, Globo H, A, Le^x/Le^y and sialyl-lactotetra were e

SUBMITTER: Saljo K 

PROVIDER: S-EPMC5638960 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature