The association of lumican polymorphisms and high myopia in a Southern Chinese population.

ABSTRACT:

Aim

To investigate the correlation between lumican (LUM) gene and high myopia in a Southern Chinese population.

Methods

The study comprised of 95 high myopia patients with a spherical equivalent ≤-6.5 diopters (D). The control group recruited 95 individuals with a spherical equivalent ranging from -0.5 D to +0.5 D. Direct sequencing was used to detect the single nucleotide polymorphisms (SNPs) of LUM gene in coding region. Genotype distributions were tested for Hardy-Weinberg disequilibrium. Genotypic and allelic frequencies were analyzed through Chi-square test or Fisher's exact test.

Results

We identified 3 SNPs of the LUM gene: LUM c.32 (rs577456426), LUM c.507 (rs17853500) and LUM c.849 (rs181915277). Among the three SNPs, the genotype and allele frequencies of rs

SUBMITTER: Wang GF 

PROVIDER: S-EPMC5638971 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature