Genetic Association of the PERIOD3 (Per3) Clock Gene with Bipolar Disorder.

ABSTRACT:

Objective

Circadian rhythms have been linked to psychiatric disorders such as Depression and Bipolar Disorder (BD). Given previous evidences of sleep/circadian disturbances as well as the genetic susceptibility for BD, we decided to investigate the possible link between the PERIOD3 (Per3) circadian gene and BD.

Methods

This is a genetic association case (BD) vs. control study of the Per3 gene. We further subdivided our BD sample into "good sleepers" (PSQI ≤5) and "poor sleepers" (PSQI>5) according to the Pittsburgh Sleep Quality Index (PSQI) global score, and then we assessed genetic association of the Per3 gene with sleep quality in the BD group.

Results

There were 209 cases and 213 controls in our sample. The GT genotype of the SNP rs707467 significantly associated

SUBMITTER: Brasil Rocha PM 

PROVIDER: S-EPMC5639137 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature