Protection against cholera from killed whole-cell oral cholera vaccines: a systematic review and meta-analysis.

ABSTRACT:

Background

Killed whole-cell oral cholera vaccines (kOCVs) are becoming a standard cholera control and prevention tool. However, vaccine efficacy and direct effectiveness estimates have varied, with differences in study design, location, follow-up duration, and vaccine composition posing challenges for public health decision making. We did a systematic review and meta-analysis to generate average estimates of kOCV efficacy and direct effectiveness from the available literature.

Methods

For this systematic review and meta-analysis, we searched PubMed, Embase, Scopus, and the Cochrane Review Library on July 9, 2016, and ISI Web of Science on July 11, 2016, for randomised controlled trials and observational studies that reported estimates of direct protection against medically

SUBMITTER: Bi Q 

PROVIDER: S-EPMC5639147 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature