Modulation of defensive reactivity by GLRB allelic variation: converging evidence from an intermediate phenotype approach.

ABSTRACT: Representing a phylogenetically old and very basic mechanism of inhibitory neurotransmission, glycine receptors have been implicated in the modulation of behavioral components underlying defensive responding toward threat. As one of the first findings being confirmed by genome-wide association studies for the phenotype of panic disorder and agoraphobia, allelic variation in a gene coding for the glycine receptor beta subunit (GLRB) has recently been associated with increased neural fear network activation and enhanced acoustic startle reflexes. On the basis of two independent healthy control samples, we here aimed to further explore the functional significance of the GLRB genotype (rs7688285) by employing an intermediate phenotype approach. We focused on the phenotype of defensive system r

SUBMITTER: Lueken U 

PROVIDER: S-EPMC5639239 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature