Polygenic loading for major depression is associated with specific medical comorbidity.

ABSTRACT: Major depressive disorder frequently co-occurs with medical disorders, raising the possibility of shared genetic liability. Recent identification of 15 novel genetic loci associated with depression allows direct investigation of this question. In cohorts of individuals participating in biobanks at two academic medical centers, we calculated polygenic loading for risk loci reported to be associated with depression. We then examined the association between such loading and 50 groups of clinical diagnoses, or topics, drawn from these patients' electronic health records, determined using a novel application of latent Dirichilet allocation. Three topics showed experiment-wide association with the depression liability score; these included diagnostic groups representing greater prevalence of moo

SUBMITTER: McCoy TH 

PROVIDER: S-EPMC5639245 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature