Role of microglial amylin receptors in mediating beta amyloid (Aβ)-induced inflammation.

ABSTRACT:

Background

Neuroinflammation in the brain consequent to activation of microglia is viewed as an important component of Alzheimer's disease (AD) pathology. Amyloid beta (Aβ) protein is known to activate microglia and unleash an inflammatory cascade that eventually results in neuronal dysfunction and death. In this study, we sought to identify the presence of amylin receptors on human fetal and murine microglia and determine whether Aβ activation of the inflammasome complex and subsequent release of cytokines is mediated through these receptors.

Methods

The presence of dimeric components of the amylin receptor (calcitonin receptor and receptor activity modifying protein 3) were first immunohistochemically identified on microglia. Purified human fetal microglial (HFM) cultures

SUBMITTER: Fu W 

PROVIDER: S-EPMC5639602 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature