Prion-like Domains Program Ewing's Sarcoma.

ABSTRACT: Prion-like domains have emerged as important drivers of neurodegenerative disease. Now, Boulay et al. establish that the translocated prion-like domain of the oncogenic EWS-FLI1 fusion protein enables phase-separation events, which inappropriately recruit chromatin-remodeling factors to elicit the aberrant transcriptional programs underlying Ewing's sarcoma.

SUBMITTER: Shorter J 

PROVIDER: S-EPMC5639709 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature