Virulence test using nematodes to prescreen Nocardia species capable of inducing neurodegeneration and behavioral disorders.

ABSTRACT:

Background

Parkinson's disease (PD) is a disorder characterized by dopaminergic neuron programmed cell death. The etiology of PD remains uncertain-some cases are due to selected genes associated with familial heredity, others are due to environmental exposure to toxic components, but over 90% of cases have a sporadic origin. Nocardia are Actinobacteria that can cause human diseases like nocardiosis. This illness can lead to lung infection or central nervous system (CNS) invasion in both immunocompromised and immunocompetent individuals. The main species involved in CNS are N. farcinica, N. nova, N. brasiliensis and N. cyriacigeorgica. Some studies have highlighted the ability of N. cyriacigeorgica to induce Parkinson's disease-like symptoms in ani

SUBMITTER: Bernardin Souibgui C 

PROVIDER: S-EPMC5639870 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature