Standardized Approach for ROI-Based Measurements of Proton Density Fat Fraction and R2* in the Liver.

ABSTRACT:

Objective

The purpose of this study was to evaluate the reproducibility (interreviewer agreement) and repeatability (intrareviewer agreement) of ROI sampling strategies to measure chemical shift-encoded (CSE) MRI-based liver proton density fat fraction (PDFF) and R2* (1 / T2*). A secondary purpose was to standardize ROI-based liver PDFF and R2* measurements by providing a compromise between measurement reproducibility and repeatability and time burden for image analysts.

Materials and methods

CSE data from two cohorts were retrospectively analyzed. Cohort A included 53 patients referred for abdominal MRI and healthy subjects recruited for a comparison study of CT and MRI. Cohort B included 37 patients with suspected liver iron overload. Three reviewers measured liver PDFF an

SUBMITTER: Campo CA 

PROVIDER: S-EPMC5639884 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature