Awake, long-term intranasal insulin treatment does not affect object memory, odor discrimination, or reversal learning in mice.

ABSTRACT: Intranasal insulin delivery is currently being used in clinical trials to test for improvement in human memory and cognition, and in particular, for lessening memory loss attributed to neurodegenerative diseases. Studies have reported the effects of short-term intranasal insulin treatment on various behaviors, but less have examined long-term effects. The olfactory bulb contains the highest density of insulin receptors in conjunction with the highest level of insulin transport within the brain. Previous research from our laboratory has demonstrated that acute insulin intranasal delivery (IND) enhanced both short- and long-term memory as well as increased two-odor discrimination in a two-choice paradigm. Herein, we investigated the behavioral and physiological effects of chronic insulin IND

SUBMITTER: Bell GA 

PROVIDER: S-EPMC5639911 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature