Cationic Nanocylinders Promote Angiogenic Activities of Endothelial Cells.

ABSTRACT: Polymers have been used extensively taking forms as scaffolds, patterned surface and nanoparticle for regenerative medicine applications. Angiogenesis is an essential process for successful tissue regeneration, and endothelial cell-cell interaction plays a pivotal role in regulating their tight junction formation, a hallmark of angiogenesis. Though continuous progress has been made, strategies to promote angiogenesis still rely on small molecule delivery or nuanced scaffold fabrication. As such, the recent paradigm shift from top-down to bottom-up approaches in tissue engineering necessitates development of polymer-based modular engineering tools to control angiogenesis. Here, we developed cationic nanocylinders (NCs) as inducers of cell-cell interaction and investigated their effect on an

SUBMITTER: Lee JB 

PROVIDER: S-EPMC5639919 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature