Poor recovery from cystic fibrosis pulmonary exacerbations is associated with poor long-term outcomes.

ABSTRACT:

Rationale

People with CF treated with IV antibiotics for a pulmonary exacerbation (PEx) frequently fail to recover to baseline FEV₁ . The long-term impact of these events has not been studied.

Objectives

To determine if a patient's spirometric recovery after a PEx is associated with time to next PEx within 1 year, the spirometric recovery after the next PEx, and/or the number of PEx episodes in the next 3 years.

Methods

We used data from the CF Foundation Patient Registry from 2004 to 2011. We randomly selected one PEx per patient that met inclusion/exclusion criteria. Patients were defined as Non-Responders if their best FEV₁ (in liters) recorded in the 3 months after the PEx was <90% of the best FEV₁ (in liters) in the 6 months befor

SUBMITTER: Sanders DB 

PROVIDER: S-EPMC5639928 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature