Protocol for the TIDAL Melanoma Study: topical imiquimod or diphenylcyclopropenone for the management of cutaneous in-transit melanoma metastases-a phase II, single centre, randomised, pilot study.

ABSTRACT:

Introduction

Patients with in-transit melanoma metastases present a therapeutic challenge. Complete surgical excision of localised disease is considered as the gold standard; however, surgery is not always acceptable and alternatives are required. Treatment results reported using imiquimod and diphenylcyclopropenone (DPCP) suggest that topical immunotherapies can be used to successfully treat select patients with melanoma metastases. A phase II, randomised, single centre, pilot study was designed to assess the clinical efficacy and safety of DPCP and imiquimod for the treatment of superficial, cutaneous in-transit melanoma metastases.

Methods and analysis

This is an open-label, non-superiority, pilot study with no treatment cross-over. Eligible patients are randomised in a 1

SUBMITTER: Read T 

PROVIDER: S-EPMC5640002 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature