Burden of non-adherence to latent tuberculosis infection drug therapy and the potential cost-effectiveness of adherence interventions in Canada: a simulation study.

ABSTRACT:

Objective

Pharmaceutical treatment of latent tuberculosis infection (LTBI) reduces the risk of progression to active tuberculosis (TB); however, poor adherence tempers the protective effect. We aimed to estimate the health burden of non-adherence, the maximum allowable cost of hypothetical new adherence interventions to be cost-effective and the potential value of existing adherence interventions for patients with low-risk LTBI in Canada.

Design

A microsimulation model of LTBI progression over 25 years.

Setting

General practice in Canada.

Participants

Individuals with LTBI who are initiating drug therapy.

Interventions

A hypothetical intervention with a range of effectiveness was evaluated. Existing drug adherence interventions including peer support, tw

SUBMITTER: Patel AR 

PROVIDER: S-EPMC5640098 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature