Effectiveness of α₂agonists for sedation in paediatric critical care: study protocol for a retrospective cohort observational study.

ABSTRACT:

Introduction

Mechanically ventilated children in paediatric intensive care units are commonly administered analgesics and sedative agents to minimise pain and distress and facilitate cooperation with medical interventions. Opioids and benzodiazepines are the most common analgesic and sedative agents but have safety concerns. The α₂ agonists clonidine and dexmedetomidine are alternative sedatives in use despite neither having robust evidence to support their use. Studies evaluating effectiveness of α₂ agonists to date have not focused on sedation-based outcomes instead focusing on opioid-sparing properties and ventilation outcomes. The aim of this study is to evaluate if an opioid-based sedation regimen, with an α₂ agonist adjunct (clonidine or dexme

SUBMITTER: Hayden JC 

PROVIDER: S-EPMC5640130 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature