A C-terminal motif contributes to the plasma membrane localization of Arabidopsis STP transporters.

ABSTRACT: Membrane trafficking is highly organized to maintain cellular homeostasis in any organisms. Membrane-embedded transporters are targeted to various organelles to execute appropriate partition and allocation of their substrates, such as ions or sugars. To ensure the fidelity of targeting and sorting, membrane proteins including transporters have sorting signals that specify the subcellular destination and the trafficking pathway by which the destination is to be reached. Here, we have identified a novel sorting signal (called the tri-aromatic motif) which contains three aromatic residues, two tryptophans and one histidine, for the plasma membrane localization of sugar transporters in the STP family in Arabidopsis. We firstly found that a C-terminal deletion disrupted the sugar uptake activit

SUBMITTER: Yamada K 

PROVIDER: S-EPMC5640241 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature