Methylene C(sp³)-H Arylation of Aliphatic Ketones Using a Transient Directing Group.

ABSTRACT: Palladium-catalyzed methylene β-C(sp³)-H arylation of aliphatic ketones using a transient directing group is developed. The use of α-benzyl β-alanine directing group that forms a six-membered chelation with palladium is crucial for promoting the methylene C(sp³)-H bond activation.

SUBMITTER: Hong K 

PROVIDER: S-EPMC5640319 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature