Clinical and histopathological features of myofibrillar myopathy in Warmblood horses.

ABSTRACT:

Background

To report a novel exertional myopathy, myofibrillar myopathy (MFM) in Warmblood (WB) horses.

Objectives

To 1) describe the distinctive clinical and myopathic features of MFM in Warmblood horses and 2) investigate the potential inheritance of MFM in a Warmblood family.

Study design

Retrospective selection of MFM cases and prospective evaluation of a Warmblood family.

Methods

Retrospectively, muscle biopsies were selected from Warmblood horses diagnosed with MFM and clinical histories obtained (n = 10). Prospectively, muscle biopsies were obtained from controls (n = 8) and a three generation WB family (n = 11). Samples were assessed for histopathology [scored 0-3], fibre types, cytoskeletal and Z disc protein aggregates, electron microscopic alteration

SUBMITTER: Valberg SJ 

PROVIDER: S-EPMC5640499 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature