A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction.

ABSTRACT: Loss of protein and organelle quality control secondary to reduced autophagy is a hallmark of aging. However, the physiologic and molecular regulation of autophagy in long-lived organisms remains incompletely understood. Here we show that the Kruppel-like family of transcription factors are important regulators of autophagy and healthspan in C. elegans, and also modulate mammalian vascular age-associated phenotypes. Kruppel-like family of transcription factor deficiency attenuates autophagy and lifespan extension across mechanistically distinct longevity nematode models. Conversely, Kruppel-like family of transcription factor overexpression extends nematode lifespan in an autophagy-dependent manner. Furthermore, we show the mammalian vascular factor Kruppel-like family of transcription fac

SUBMITTER: Hsieh PN 

PROVIDER: S-EPMC5640649 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature