Ontology highlight
ABSTRACT:
SUBMITTER: Roost MS
PROVIDER: S-EPMC5640655 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Roost Matthias S MS Slieker Roderick C RC Bialecka Monika M van Iperen Liesbeth L Gomes Fernandes Maria M MM He Nannan N Suchiman H Eka D HED Szuhai Karoly K Carlotti Françoise F de Koning Eelco J P EJP Mummery Christine L CL Heijmans Bastiaan T BT Chuva de Sousa Lopes Susana M SM
Nature communications 20171013 1
Determining cell identity and maturation status of differentiated pluripotent stem cells (PSCs) requires knowledge of the transcriptional and epigenetic trajectory of organs during development. Here, we generate a transcriptional and DNA methylation atlas covering 21 organs during human fetal development. Analysis of multiple isogenic organ sets shows that organ-specific DNA methylation patterns are highly dynamic between week 9 (W9) and W22 of gestation. We investigate the impact of reprogrammi ...[more]