Informatic analysis reveals Legionella as a source of novel natural products.

ABSTRACT: Microbial natural products are a crucial source of bioactive molecules and unique chemical scaffolds. Despite their importance, rediscovery of known natural products from established productive microbes has led to declining interest, even while emergent genomic data suggest that the majority of microbial natural products remain to be discovered. Now, new sources of microbial natural products must be defined in order to provide chemical scaffolds for the next generation of small molecules for therapeutic, agricultural, and industrial purposes. In this work, we use specialized bioinformatic programs, genetic knockouts, and comparative metabolomics to define the genus Legionella as a new source of novel natural products. We show that Legionella spp. hold a diverse collection of

SUBMITTER: Johnston CW 

PROVIDER: S-EPMC5640695 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature