Comparative Genomics of Sibling Species of Fonsecaea Associated with Human Chromoblastomycosis.

ABSTRACT: Fonsecaea and Cladophialophora are genera of black yeast-like fungi harboring agents of a mutilating implantation disease in humans, along with strictly environmental species. The current hypothesis suggests that those species reside in somewhat adverse microhabitats, and pathogenic siblings share virulence factors enabling survival in mammal tissue after coincidental inoculation driven by pathogenic adaptation. A comparative genomic analysis of environmental and pathogenic siblings of Fonsecaea and Cladophialophora was undertaken, including de novo assembly of F. erecta from plant material. The genome size of Fonsecaea species varied between 33.39 and 35.23 Mb, and the core genomes of those species comprises almost 70% of the genes. Expansi

SUBMITTER: Vicente VA 

PROVIDER: S-EPMC5640708 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature