Reduced Apparent Diffusion Coefficient in Various Brain Areas following Low-Intensity Transcranial Ultrasound Stimulation.

ABSTRACT: Diffusion of water molecules closely related to physiological and pathological information of brain tissue. Low-intensity transcranial ultrasound stimulation (TUS) has advantages of noninvasive, high spatial resolution and penetration depth. Previous studies have demonstrate that TUS can modulate neuronal activity and alter cortical hemodynamic. However, how TUS affect diffusion of water molecules remain unclear. In this paper, in order to evaluate the effect of low-intensity TUS on the diffusion of water molecules in brain tissue, diffusion-weighted magnetic resonance (MR) imaging was performed in 19 healthy Sprague-Dawley rats in sham surgery group (six rats) and TUS group (thirteen rats) Subsequently, rats were stimulated by low-intensity transcranial ultrasound for 5 min in TUS group.

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC5640877 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature