Identification of 15 candidate structured noncoding RNA motifs in fungi by comparative genomics.

ABSTRACT:

Background

With the development of rapid and inexpensive DNA sequencing, the genome sequences of more than 100 fungal species have been made available. This dataset provides an excellent resource for comparative genomics analyses, which can be used to discover genetic elements, including noncoding RNAs (ncRNAs). Bioinformatics tools similar to those used to uncover novel ncRNAs in bacteria, likewise, should be useful for searching fungal genomic sequences, and the relative ease of genetic experiments with some model fungal species could facilitate experimental validation studies.

Results

We have adapted a bioinformatics pipeline for discovering bacterial ncRNAs to systematically analyze many fungal genomes. This comparative genomics pipeline integrates information on conserv

SUBMITTER: Li S 

PROVIDER: S-EPMC5640933 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature