Gene expression modules in primary breast cancers as risk factors for organotropic patterns of first metastatic spread: a case control study.

ABSTRACT:

Background

Metastases from primary breast cancers can involve single or multiple organs at metastatic disease diagnosis. Molecular risk factors for particular patterns of metastastic spread in a clinical population are limited.

Methods

A case-control design including 1357 primary breast cancers was used to study three distinct clinical patterns of metastasis, which occur within the first six months of metastatic disease: bone and visceral metasynchronous spread, bone-only, and visceral-only metastasis. Whole-genome expression profiles were obtained using whole genome (WG)-DASL assays from formalin-fixed paraffin-embedded (FFPE) samples. A systematic protocol was developed for handling FFPE samples together with stringent data quality controls to identify robust expression pr

SUBMITTER: Lawler K 

PROVIDER: S-EPMC5640935 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature