A strategy for evaluating pathway analysis methods.

ABSTRACT:

Background

Researchers have previously developed a multitude of methods designed to identify biological pathways associated with specific clinical or experimental conditions of interest, with the aim of facilitating biological interpretation of high-throughput data. Before practically applying such pathway analysis (PA) methods, we must first evaluate their performance and reliability, using datasets where the pathways perturbed by the conditions of interest have been well characterized in advance. However, such 'ground truths' (or gold standards) are often unavailable. Furthermore, previous evaluation strategies that have focused on defining 'true answers' are unable to systematically and objectively assess PA methods under a wide range of conditions.

Results

In this work,

SUBMITTER: Yu C 

PROVIDER: S-EPMC5640951 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature