Xuefu zhuyu decoction improves cognitive impairment in experimental traumatic brain injury via synaptic regulation.

ABSTRACT: An overarching consequence of traumatic brain injury (TBI) is the cognitive impairment. It may hinder individual performance of daily tasks and determine people's subjective well-being. The damage to synaptic plasticity, one of the key mechanisms of cognitive dysfunction, becomes the potential therapeutic strategy of TBI. In this study, we aimed to investigate whether Xuefu Zhuyu Decoction (XFZYD), a traditional Chinese medicine, provided a synaptic regulation to improve cognitive disorder following TBI. Morris water maze and modified neurological severity scores were performed to assess the neurological and cognitive abilities. The PubChem Compound IDs of the major compounds of XFZYD were submitted into BATMAN-TCM, an online bioinformatics analysis tool, to predict the druggable targets r

SUBMITTER: Zhou J 

PROVIDER: S-EPMC5641112 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature