Association of four genetic polymorphisms in the vascular endothelial growth factor-A gene and development of ovarian cancer: a meta-analysis.

ABSTRACT: This study meta-analyzed the literature on possible association of four polymorphisms (+936C/T, -460C/T, -2578C/A and -1154G/A) in the vascular endothelial growth factor (VEGF)-A gene with risk of ovarian cancer. Meta-analysis of 7 case-control studies involving +936C/T, 4 studies involving -460C/T, 4 studies involving -2578C/A and 2 studies involving -1154G/A showed significant association between -460C/T and ovarian cancer risk. This risk was observed in the total population (allelic model, OR 1.80, 95% CI 1.26-2.59, P = 0.001; recessive model, OR 1.84, 95% CI 1.13-2.98, P = 0.01; dominant model, OR 0.51, 95% CI 0.39-0.67, P < 0.001; homozygous model, OR 2.48, 95% CI 1.72-3.56, P < 0.001; heterozygous model, OR 1.67, 95% CI 1.26-2.21, P < 0.001) and in

SUBMITTER: Xu CH 

PROVIDER: S-EPMC5641192 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature