Synaptic activity protects against AD and FTD-like pathology via autophagic-lysosomal degradation.

ABSTRACT: Changes in synaptic excitability and reduced brain metabolism are among the earliest detectable alterations associated with the development of Alzheimer's disease (AD). Stimulation of synaptic activity has been shown to be protective in models of AD beta-amyloidosis. Remarkably, deep brain stimulation (DBS) provides beneficial effects in AD patients, and represents an important therapeutic approach against AD and other forms of dementia. While several studies have explored the effect of synaptic activation on beta-amyloid, little is known about Tau protein. In this study, we investigated the effect of synaptic stimulation on Tau pathology and synapses in in vivo and in vitro models of AD and frontotemporal dementia (FTD). We found that chronic DBS or chemically induced synaptic stimulation

SUBMITTER: Akwa Y 

PROVIDER: S-EPMC5641448 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature