Prognostic value of programmed death-ligand 1 (PD-L1) expression in ovarian clear cell carcinoma.

ABSTRACT:

Objective

Programmed death-ligand 1 (PD-L1) was expressed in various tumors and antibodies targeting its receptor programmed cell death-1 (PD-1) are emerging cancer therapeutics. This study was designed to evaluate the expression of PD-L1 and its correlation with clinicopathologic features and clinical outcomes in ovarian clear cell carcinoma (OCCC).

Methods

The PD-L1 expression was measured by tissue-microarray-based immunohistochemistry from 122 eligible patients diagnosed with OCCC. The associations of clinicopathologic features with progression-free survival (PFS) and overall survival (OS) were analyzed by Kaplan-Meier method and multivariate analysis was further performed by Cox regression model.

Results

Overall, high PD-L1 expression (PD-L1(high)) was observed i

SUBMITTER: Zhu J 

PROVIDER: S-EPMC5641527 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature