Quantitative imaging outperforms molecular markers when predicting response to chemoradiotherapy for rectal cancer.

ABSTRACT:

Background and purpose

To explore the integration of imaging and molecular data for response prediction to chemoradiotherapy (CRT) for rectal cancer.

Material and methods

Eighty-five rectal cancer patients underwent preoperative CRT. ¹⁸F-FDG PET/CT and diffusion-weighted imaging (DWI) were acquired before (TP1) and during CRT (TP2) and prior to surgery (TP3). Inflammatory cytokines and gene expression were analysed. Tumour response was defined as ypT0-1N0. Multivariate models were built combining the obtained parameters. Final models were calculated on the data combination with the highest AUC.

Results

Twenty-two patients (26%) achieved ypT0-1N0 response. ¹⁸F-FDG PET/CT had worse predictive performance than DWI and T2-volumetry (AUC 0.61±0.04, 0.

SUBMITTER: Joye I 

PROVIDER: S-EPMC5641595 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature