Angiopoietin-like protein 4 is an exercise-induced hepatokine in humans, regulated by glucagon and cAMP.

ABSTRACT:

Objective

Angiopoietin-like protein-4 (ANGPTL4) is a circulating protein that is highly expressed in liver and implicated in regulation of plasma triglyceride levels. Systemic ANGPTL4 increases during prolonged fasting and is suggested to be secreted from skeletal muscle following exercise.

Methods

We investigated the origin of exercise-induced ANGPTL4 in humans by measuring the arterial-to-venous difference over the leg and the hepato-splanchnic bed during an acute bout of exercise. Furthermore, the impact of the glucagon-to-insulin ratio on plasma ANGPTL4 was studied in healthy individuals. The regulation of ANGPTL4 was investigated in both hepatic and muscle cells.

Results

The hepato-splanchnic bed, but not the leg, contributed to exercise-induced plasma ANGPTL4. F

SUBMITTER: Ingerslev B 

PROVIDER: S-EPMC5641605 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature