Cdkal1, a type 2 diabetes susceptibility gene, regulates mitochondrial function in adipose tissue.

ABSTRACT:

Objectives

Understanding how loci identified by genome wide association studies (GWAS) contribute to pathogenesis requires new mechanistic insights. Variants within CDKAL1 are strongly linked to an increased risk of developing type 2 diabetes and obesity. Investigations in mouse models have focused on the function of Cdkal1 as a tRNA^Lys modifier and downstream effects of Cdkal1 loss on pro-insulin translational fidelity in pancreatic β-cells. However, Cdkal1 is broadly expressed in other metabolically relevant tissues, including adipose tissue. In addition, the Cdkal1 homolog Cdk5rap1 regulates mitochondrial protein translation and mitochondrial function in skeletal muscle. We tested whether adipocyte-specific Cdkal1 deletion alters systemic glucose homeostasis or adipos

SUBMITTER: Palmer CJ 

PROVIDER: S-EPMC5641635 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature