Brown adipocytes can display a mammary basal myoepithelial cell phenotype in vivo.

ABSTRACT:

Objective

Previous work has suggested that white adipocytes may also show a mammary luminal secretory cell phenotype during lactation. The capacity of brown and beige/brite adipocytes to display a mammary cell phenotype and the levels at which they demonstrate such phenotypes in vivo is currently unknown.

Methods

To investigate the putative adipocyte origin of mammary gland cells, we performed genetic lineage-labeling experiments in BAT and the mammary glands.

Results

These studies indicated that the classic brown adipocytes (Ucp1⁺) and subcutaneous beige/brite adipocytes (Ucp1^-/+) were found in the mammary gland during lactation, when they exhibited a mammary myoepithelial phenotype. Up to 2.5% of the anterior dorsal interscapular mammary myoepi

SUBMITTER: Li L 

PROVIDER: S-EPMC5641686 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature