Monoamine Oxidase A (<i>MAOA</i>) Gene and Personality Traits from Late Adolescence through Early Adulthood: A Latent Variable Investigation.

ABSTRACT: Very few molecular genetic studies of personality traits have used longitudinal phenotypic data, therefore molecular basis for developmental change and stability of personality remains to be explored. We examined the role of the monoamine oxidase A gene (MAOA) on extraversion and neuroticism from adolescence to adulthood, using modern latent variable methods. A sample of 1,160 male and 1,180 female participants with complete genotyping data was drawn from a British national birth cohort, the MRC National Survey of Health and Development (NSHD). The predictor variable was based on a latent variable representing genetic variations of the MAOA gene measured by three SNPs (rs3788862, rs5906957, and rs979606). Latent phenotype variables were constructed using psychometric methods

SUBMITTER: Xu MK 

PROVIDER: S-EPMC5641687 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature