Ontology highlight
ABSTRACT:
SUBMITTER: Dingjan I
PROVIDER: S-EPMC5641923 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Dingjan Ilse I Paardekooper Laurent M LM Verboogen Daniëlle R J DRJ von Mollard Gabriele Fischer GF Ter Beest Martin M van den Bogaart Geert G
European journal of cell biology 20170623 7
Cross-presentation of foreign antigen in major histocompatibility complex (MHC) class I by dendritic cells (DCs) requires activation of the NADPH-oxidase NOX2 complex. We recently showed that NOX2 is recruited to phagosomes by the SNARE protein VAMP8 where NOX2-produced reactive oxygen species (ROS) cause lipid oxidation and membrane disruption, promoting antigen translocation into the cytosol for cross-presentation. In this study, we extend these findings by showing that VAMP8 is also involved ...[more]