HLA Amino Acid Polymorphisms and Kidney Allograft Survival.

ABSTRACT:

Background

The association of HLA mismatching with kidney allograft survival has been well established. We examined whether amino acid (AA) mismatches (MMs) at the antigen recognition site of HLA molecules represent independent and incremental risk factors for kidney graft failure (GF) beyond those MMs assessed at the antigenic (2-digit) specificity.

Methods

Data on 240 024 kidney transplants performed between 1987 and 2009 were obtained from the Scientific Registry of Transplant Recipients. We imputed HLA-A, -B, and -DRB1 alleles and corresponding AA polymorphisms from antigenic specificity through the application of statistical and population genetics inferences. GF risk was evaluated using Cox proportional-hazards regression models adjusted for covariates including patien

SUBMITTER: Kamoun M 

PROVIDER: S-EPMC5642346 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature