MiR-196a2 and lung cancer in Chinese non-smoking females: a genetic association study and expression analysis.

ABSTRACT:

Background

The common polymorphism rs11614913 in miR-196a2 might be associated with lung cancer risk for non-smoking females in northeast China.

Methods

The genotypes of rs11614913 in miR-196a2 were determined by a case-control study including 1003 patients with lung cancer and 1003 healthy controls. The tissues were detected to assess the miRNA expression. Secondary structures of miR-196a2 were predicted.

Results

There was a significant association between miR-196a2 rs11614913 and lung cancer risk in Chinese non-smoking females. Individuals carrying TC or CC genotype had increased risk of lung cancer compared with TT genotype (adjusted risks were 1.63 and 1.67). The C allele was associated with a higher risk of lung cancer with a significant risk of 1.27. The similar

SUBMITTER: Yin Z 

PROVIDER: S-EPMC5642605 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature