Fluids in Sepsis and Septic Shock (FISSH): protocol for a pilot randomised controlled trial.

ABSTRACT:

Introduction

Observational evidence suggests physiological benefits and lower mortality with lower chloride solutions; however, 0.9% saline remains the most widely used fluid worldwide. Given uncertainty regarding the association of lower chloride on mortality, it is unlikely that practice will change without direct randomised clinical trial (RCT) evidence. This pilot RCT will investigate the feasibility of a large-scale trial directly comparing low chloride with high chloride fluids in patients with septic shock.

Methods and analysis

This is a randomised, concealed, blinded parallel-group multicentre pilot trial. We will include adult critically ill patients with septic shock, defined as ongoing hypotension despite 1 L of fluid, or a serum lactate >4 mmol/L, who are within

SUBMITTER: Rochwerg B 

PROVIDER: S-EPMC5642672 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature