Rationale and study design for an individualised perioperative open-lung ventilatory strategy with a high versus conventional inspiratory oxygen fraction (iPROVE-O2) and its effects on surgical site infection: study protocol for a randomised controlled trial.

ABSTRACT:

Introduction

Surgical site infection (SSI) is a serious postoperative complication that increases morbidity and healthcare costs. SSIs tend to increase as the partial pressure of tissue oxygen decreases: previous trials have focused on trying to reduce them by comparing high versus conventional inspiratory oxygen fractions (FIO₂) in the perioperative period but did not use a protocolised ventilatory strategy. The open-lung ventilatory approach restores functional lung volume and improves gas exchange, and therefore it may increase the partial pressure of tissue oxygen for a given FIO₂. The trial presented here aims to compare the efficacy of high versus conventional FIO₂ in reducing the overall incidence of SSIs in patients by implementing a protoco

SUBMITTER: Ferrando C 

PROVIDER: S-EPMC5642673 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature