Oral glucocorticoid use and osteonecrosis in children and adults with chronic inflammatory diseases: a population-based cohort study.

ABSTRACT:

Objectives

We studied oral glucocorticoids and osteonecrosis, a rare but serious bone disease, in individuals with various chronic inflammatory diseases. We hypothesised that we would find stronger associations in adults versus children and in people with autoimmune diseases.

Design

Retrospective cohort study.

Setting

Population-representative data (1994-2013) from general practices in the UK.

Participants

Children and adults diagnosed with asthma; inflammatory bowel disease; juvenile, psoriatic or rheumatoid arthritis; psoriasis; or systemic lupus.

Exposures

Oral glucocorticoid patterns.

Primary and secondary outcome measures

Diagnosed osteonecrosis (primary) and osteonecrosis plus clinical features (eg, symptoms, pain medication, surgical repair

SUBMITTER: Horton DB 

PROVIDER: S-EPMC5642748 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature