Association and clinical utility of NAT2 in the prediction of isoniazid-induced liver injury in Singaporean patients.

ABSTRACT:

Background and aims

Isoniazid (INH) is part of the first-line-therapy for tuberculosis (TB) but can cause drug-induced liver injury (DILI). Several candidate single nucleotide polymorphisms (SNPs) have been previously identified but the clinical utility of these SNPs in the prediction of INH-DILI remains uncertain. The aim of this study was to assess the association between selected candidate SNPs and the risk of INH-DILI and to assess the clinical validity of associated variants in a Singaporean population.

Methods

This was a case-control study where 24 INH-DILI cases and 79 controls were recruited from the TB control unit in a tertiary hospital. Logistic regression was used to test for the association between candidate SNPs and INH-DILI. NAT2 acetylator status was inferred

SUBMITTER: Chan SL 

PROVIDER: S-EPMC5642896 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature