Personalized management of asthma exacerbations: lessons from genetic studies.

ABSTRACT:

Introduction

The genetics of severe asthma and asthma exacerbations are distinct from milder forms of asthma. Gene-environmental interactions contribute to the complexity and heterogeneity of severe asthma and asthma exacerbations, and pharmacogenomic studies have also identified genes that affect susceptibility to asthma exacerbations.

Areas covered

Studies on the genetics, gene-environment interactions, and pharmacogenomics of asthma exacerbations are reviewed. Multiple individual genetic variants have been identified to be associated with asthma exacerbations but each genetic polymorphism explains only a fraction of the disease and by itself is not able to translate into clinical practice. Research is shifting from candidate gene studies and genome wide association studie

SUBMITTER: Wang AL 

PROVIDER: S-EPMC5642928 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature