Genetic risk factors for serious infections in inflammatory bowel diseases.

ABSTRACT:

Introduction

Immunosuppression, the cornerstone of management of Crohn's disease (CD) and ulcerative colitis (UC) (inflammatory bowel diseases; IBD) is associated with an increased risk of serious infections that is inadequately predicted by clinical risk factors. The role of genetics in determining susceptibility to infections is unknown.

Methods

From a prospective-consented patient registry, we identified IBD patients with serious infections requiring hospitalization. Analysis was performed to identify IBD-related and non-IBD related immune response loci on the Immunochip that were associated with serious infections and a genetic risk score (GRS) representing the cumulative burden of the identified single nucleotide polymorphisms was calculated. Multivariable logistic regr

SUBMITTER: Sasidharan S 

PROVIDER: S-EPMC5642969 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature