Colonic transcriptional response to 1α,25(OH)₂ vitamin D₃ in African- and European-Americans.

ABSTRACT: Colorectal cancer (CRC) is a significant health burden especially among African Americans (AA). Epidemiological studies have correlated low serum vitamin D with CRC risk, and, while hypovitaminosis D is more common and more severe in AA, the mechanisms by which vitamin D modulates CRC risk and how these differ by race are not well understood. Active vitamin D (1α,25(OH)₂D₃) has chemoprotective effects primarily through transcriptional regulation of target genes in the colon. We hypothesized that transcriptional response to 1α,25(OH)₂D₃ differs between AA and European Americans (EA) irrespective of serum vitamin D and that regulatory variants could impact transcriptional response. We treated ex vivo colon cultures from 34 healthy subjects (16 AA a

SUBMITTER: Alleyne D 

PROVIDER: S-EPMC5642973 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature