Association Between Substance Use Disorder and Polygenic Liability to Schizophrenia.

ABSTRACT:

Background

There are high levels of comorbidity between schizophrenia and substance use disorder, but little is known about the genetic etiology of this comorbidity.

Methods

We tested the hypothesis that shared genetic liability contributes to the high rates of comorbidity between schizophrenia and substance use disorder. To do this, polygenic risk scores for schizophrenia derived from a large meta-analysis by the Psychiatric Genomics Consortium were computed in three substance use disorder datasets: the Collaborative Genetic Study of Nicotine Dependence (ascertained for tobacco use disorder; n = 918 cases; 988 control subjects), the Collaborative Study on the Genetics of Alcoholism (ascertained for alcohol use disorder; n = 643 cases; 384 control subjects), and the Family S

SUBMITTER: Hartz SM 

PROVIDER: S-EPMC5643224 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature