Tissue and plasma levels of galectins in patients with high grade serous ovarian carcinoma as new predictive biomarkers.

ABSTRACT: Galectins are moving closer to center stage in detecting glycosylation aberration in cancer cells. Here, we have investigated the expression of galectins in ovarian cancer (OC) and examined their potential as biomarkers in tissues and blood plasma samples of high grade serous ovarian carcinoma (HGSC) patients. In tissues, we found that increased protein expression of stromal gal-1 and epithelial gal-8/9 was associated with a poor response to treatment of HGSC patients. Gal-8/9 were both independent predictors of chemoresistance and overall survival (OS), respectively. This galectin signature increased the predictive value of the cancer antigen 125 (CA125) on 5-year disease-free survival (DFS), post-chemotherapy treatment and 5-year OS. In CA125^LOW patients, epithelial gal-9 was

SUBMITTER: Labrie M 

PROVIDER: S-EPMC5643335 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature