Chronic hepatitis C liver microenvironment: role of the Th17/Treg interplay related to fibrogenesis.

ABSTRACT: The role of the different lymphocyte populations in liver microenvironment of chronic hepatitis C (CHC) patients is still matter of debate. Since Th17 and Treg have opposite functions, their balance could affect disease progression. The aim was to explore liver microenvironment and its peripheral blood counterpart in adult CHC patients. CD4⁺ lymphocytes were predominant in the liver, with high Foxp3⁺ but low IL-17A⁺ frequency. IL-17A⁺ lymphocytes and IL-17A⁺/Foxp3⁺ ratio displayed association with advanced fibrosis (p = 0.0130; p = 0.0236, respectively), while Foxp3⁺ lymphocytes and IL-10 expression level inversely correlated with fibrosis severity (p = 0.0381, p = 0.0398, respectively). TGF-β/IL-6 ratio correlate

SUBMITTER: Rios DA 

PROVIDER: S-EPMC5643436 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature